I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
She basically went against the narrative that say there are more than two genders, refusing to back down. And defended women. https://www.glamour.com/story/a-complete-breakdown-of-the-jk-rowling-transgender-comments-controversy