I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
I think she was the author I listened to at the tail end of an interview. The interviewer asked something like if there is hope after all this tragedy or something, and the author said no. Everything was bleak and awful. You could hear that sentiment in her voice.