I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
I’ve not heard of anyone targeting her family, but I wouldn’t exactly be surprised. I think because of her recognisability the internet is probably her main source of new / fresh social contact now and so it’s a self-reinforcing problem.