I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Neal Peart, drummer for Rush, wrote some books. Lost his daughter and first wife later.
It’s Neil, with an i. He later remarried and had another daughter, and retired from touring in 2015. He died of glioblastoma (brain cancer) in early 2020.
I have all his books. He was a very good writer. My favorite is the motorcycle trip around America (Ghost Rider)