I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Joan Didion
In 2003, Didion’s daughter Quintana Roo Dunne developed pneumonia that progressed to septic shock and she was comatose in an intensive-care unit when Didion’s husband suddenly died of a heart attack on December 30. She wrote The Year of Magical Thinking, in response to all that.