I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
I’m bummed about not getting to read Z is for Zero, but I respect the hell out of Sue for not letting a ghostwriter get ahold of it. She was so talented, and the Kinsey books are so good, it would be a tragedy to turn her into a VC Andrews