I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Philip k dick was poor most of his life and suffered from some pretty severe mental issues.
There was a story where the butcher he went to caught on that he was buying low-grade meat that was supposed to be for animals for himself.