I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Mervyn Peake, creator of Gormenghast and brilliant illustrator. Developed Parkinson’s and dementia in his 40’s, losing his ability to draw and write; died at 57.
Came here to mention Peake. He was insanely talented and the world only got to see a glimpse of what he was capable of.