I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
He also married his 14 year old cousin, but my understanding is that the marriage may have been to prevent her from shipping off somewhere and him losing another beloved woman. He loved his best friend’s mom who died of a brain disease and his wife died if TB as did his foster mother.