I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
If you haven’t seen it, I recommend the movie The Whole Wide World. It’s not a comprehensive Howard biopic because it’s based on the memoir of Novalyne Price Ellis, but it does a good job of capturing his obsessions and awkwardness. Great performances by Renée Zelleweger and Vincent D’Onofrio.
It’s on Tubi.
Second this. That movie made me cry.