I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
For another reason entirely, Eric Nylund basically wrote the book on Halo’s universe outside the games. And his Halo Books were good.
Then they dumped him and hired Karen Traviss to shit all over his good work with her military fetish complex.