I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Kurt Vonnegut’s writing is something I’ve only ever been able to describe as written PTSD. Everything he wrote was brilliant and darkly hilarious, but his life story (especially his mother’s suicide and his experience in Dresden) is horrific, and so much of the point/message behind his writing is so bleak. Slaughterhouse Five is brutal. I hope he got some peace as time went on.