I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
You should listen to Shaun’s video on the Harry Potter series. He pointed out the meanness towards fat characters and also the way it’s treated differently in “good” vs “bad” characters.