Not including short story collections, poetry collections, anthologies, etc.
For me, I believe it’s Oroonoko by Aphra Behn because it was on the syllabus for three different classes that I took in college. Other than that, the most I’ve read a single book is twice, and that was Telegraph Avenue by Michael Chabon. I’ve read Dracula 1.5 times. Didn’t finish it the second time around.
The Harry Potter series. Every time a new one came out, I re-read the whole series. And I still re-read it every few years now.