I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Marcel Proust. Guy wrote tens of thousands of pages. And he was not only in the closet until he died, he was basically literally in the closet 24/7 (well, bedroom)