I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
Probably Dr Paul Kalanithi, author of “When Breath Becomes Air”. An autobiography about finishing his residency, being diagnosed with cancer and starting a family. I know a big message in the book is that he doesn’t want pity, however he seemed like an amazing man who deserved so much more time to appreciate the life he created with his wife.