We have a choice in how we react and what we choose to do with what we have been given. So no you aren’t doomed you still have choices. You may not have control over your depression (yet) but you do have a choice over how you react and what you do with your life. Radical acceptance - choosing to make the best of what you have been given and finding/creating meaning.
Diane and her comments about good damage haunt me a lot. I still haven’t unpackaged it fully in my life but I know it hurts so deep for a reason. Also Ruthie - when PC was telling Bojack the story was made up. I don’t think I have suffered such a major emotional backlash and burst out bawling.